My sex drive/ orgasm intensity was pretty harshly dampened for the year I was on Effexor, and the 2 months on Latuda completely killed my drive and made orgasms almost painful. So I’m definitely not complaining! More just wondering if this is common, since Google has not given me anything helpful thus far and there is no way in Best Answer: Have you considered trying something else for the anxiety that won't interfere w/ your sex drive? A benzo perhaps. I also take 300mg of Wellbutrin, which helped the depression. I have to say in my experience taking Wellbutrin, it definitely increasing your sex drive or at least brings it to the level of normal. I have taken most of all the SSRIs and my sex drive had been lowered taking them. The Happy, Sexy, Skinny, Pill? Wellbutrin, an antidepressant that can spur weight loss and boost libido, is on everyone's lips. Sari Botton reveals why she's on auto-refill. I have been on Wellbutrin SR 150 mg twice a day for about 6 weeks now. WOW WOW WOW is all I can say. I used to have a healthy sex drive until I had my two kids who are now 14 and 11, then has the depression got worse through the years, often times it seemed as my sex drive was dead and I am only 33 years old. Wellbutrin XL @ 300 mg makes me hypomanic and my mind races too much to enjoy sex; Wellbutrin XL @ 150 mg keeps me erect, focused on sex, gives me a strong libido and is great and curbing cravings for food. Wellbutrin definitely lowered my sex drive, but worse than that, sex just sucked when I did have it. It's relatively uncommon to have sexual side effects at all on wellbutrin, but since it does mess with those neurotransmitters and hormones and junk, there's always a possibility of something changing. These activities can help women shift into their sex self from their role as mother, wife, employer, or employee, says Ellison. It would also help women to be more pleasure-oriented rather than. I have noticed lately that I have had little to no sex drive at all. I am only 25, and I am sexually active with my boyfriend. However, lately I just have not been interested in sex or anything sexual at all.